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Skin Disorders and TreatmentAcrochordons |
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Bullous PemphigoidBullous pemphigoid is an skin condition which is more common than pemphigus. It affects the people in later life (usually over 60 years old) and the mucosal involvement is very rare. Auto antibodies against a 230 kDa or 180 kDa hemidesmosomal protein ('bullous pemphigoid antigens 1 and 2') play an aetiological role in Bullous pemphigoid. Bullous Pemphigoid is a rare, autoimmune, chronic skin disorder. It is characterized by blistering. This disorder occurs mostly in elderly people. The disorder may occur in various forms, from no symptoms. It looks like mild redness and irritation, to multiple blisters. It is a chronic, autoimmune, subepidermal, blistering skin disease that rarely involves mucous membranes. Generalized blistering occurs in and under the upper layers of the skin and usually subsides spontaneously within several. In some rare cases of Bullous Pemphigoid, complications such as pneumonia may develop. Bullous pemphigoid CausesThe exact cause of Bullous Pemphigoid is a autoimmune reaction by the body against the glue holding the skin together; Autoimmune disorders are generated when the body's natural defenses (e.g., the immune system with its antibodies) against "foreign" or invading organisms, attack healthy tissue for unknown reasons. It is caused by autoantibody mediated disruption of adhesion between basal keratocytes and the basement membrane, i.e., antibodies there binds the antigens of bullous pemphigoid. Bullous Pemphigoid Symptoms
Bullous pemphigoid TreatmentIn treatment of bullous pemphigoid the coordination between a dermatologist and the patient is very necessary. Usually the treatment prolonged for a huge time period. So coordination is needed. Although bullous pemphigoid is a medical condition which can be irritating and troublesome, it is important to keep in mind that there are various ways in which individuals can attempt to control the occurrence of this rare condition. Treatment often starts in hospital to ensure good control and so that proper dressings can be put on the blisters and raw areas. Some patients can come off their treatment gradually, usually after a few months; others will need to go on with lower doses for a long time. Calcium and vitamin D supplements, or other medications, should be given to keep your bones strong. This is with high-dose oral prednisolone (30-60 mg daily) and steroid-sparing agents such as azathioprine. In general, disease control is easier than with pemphigus. Often, treatment can be withdrawn after 2-3 years. However, pemphigoid treatment often causes side-effects, especially as most patients are elderly. Occasionally localized disease can be controlled with potent topical steroids or oral dapsone. Treatment is focused on relief of symptoms and prevention of infection. Corticosteroids are the treatment of choice. They are given by mouth or by injection. Topical (applied to a localized area of the skin) corticosteroids may also be used on early, localized lesions. Approximately 70% to 80% of patients with active BP have circulating antibodies to one or more basement membrane zone antigens. On direct immunofluorescence, the antibodies are deposited in a thin linear pattern; and on immune electron microscopy, they are present in the lamina lucida. Do not stop taking a corticosteroid drug suddenly. These types of drugs must be tapered off slowly under a doctor's supervision. |
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